Bioactive Small Molecules
eMolecules 100299-08-9 | AstaTech | PEMIROLAST POTASSIUM | 25mg | 718060471 | T71519 | 98 | MFCD01690051 | 266.305 | C10H7KN6O
Medchem Express | Asivatrep | 1mg | 446261777 | HY-12777 | 1005168-10-4 | MFCD28502100 | 491.480 | C21H22F5N3O3S
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Cell Signaling Technology FastScantm Phospho-Akt Ser473 ELISA Kit 10 Kit
FastScantm Phospho-Akt Ser473 ELISA Kit 10 Kit
Medchemexpress LLC GRGDSP | 91037-75-1 | 99.95% | 587.58 | 100 MG
GRGDSP is a synthetic linear RGD peptide and an integrin inhibitor. It can inhibit the adherence of tumor cells to endothelial cells of blood vessels and limit metastasis.
- Integrin inhibitor
- Inhibits adherence of tumor cells to endothelial cells
- Limits metastasis
- Used in integrin research as a soluble RGD-based peptide
- Can be used to modify cardiovascular implants to promote endothelialization
Medchemexpress LLC 4-(2-methyl-3-propan-2-ylimidazol-4-yl)-N-(4-methylsulfonylphenyl)pyrimidin-2-amine | 602306-29-6 | MFCD11112135 | 99.9% | 371.46 g/mol | C18H21N5O2S | 500 MG
AZD-5438 is a small-molecule inhibitor of cyclin-dependent kinases CDK1, CDK2, and CDK9, characterized by low nanomolar potency in biochemical assays. It is used in research on cell-cycle regulation, cancer pharmacology, and radiosensitization studies, and has a molecular formula of C18H21N5O2S with a molecular weight of 371.46 g/mol.
- Potent inhibition of CDK1, CDK2, and CDK9 with reported IC50s of 16 nM, 6 nM, and 20 nM.
- High purity (>99.9% by HPLC) suitable for biochemical and cell-based assays.
- Supplied as a 500 mg research-grade solid for laboratory use.
- Molecular formula C18H21N5O2S and molecular weight 371.46 g/mol for precise dosing and calculations.
- Applicable for studies of cell-cycle regulation, cancer mechanisms, and radiosensitization.
Medchemexpress LLC Parmodulin 2 (ML161) | 423735-93-7 | 99.8% | 361.23 | 1 ML
Parmodulin 2 (ML161) | 423735-93-7 | 99.8% | 361.23 | 1 ML
Cayman Chemical BenzquInamIdehydrochlorIde 5mg
An antiemetic and antagonist of dopamine D2-, D4-, and D3 receptors (Kis = 1,365, 691, and 545 nM for α2A-, α2B-, and α2C-AR, respectively); has been mistakenly identified as an antagonist of histamine H1 receptors and M1-5 mAChRs; inhibits conditioned avoidance in the shuttle box test in dogs (ED50 = 2.77 mg/kg); inhibits apomorphine-induced emesis in dogs (ED50 = 0.69 mg/kg); induces tachycardia, increases blood levels of norepinephrine, and temporarily decreases systolic and diastolic blood pressure, which revert to baseline within one minute in normotensive dogs at 0.5-5 mg/kg
Medchemexpress LLC 4-(3-chloro-4-fluoroanilino)-6-(pyridin-3-ylmethylamino)-1,7-naphthyridine-3-carbonitrile | 871307-18-5 | MFCD12405303 | 99.4% | 404.83 g/mol | C21H14ClFN6 | 10MM 1ML
Tpl2 Kinase Inhibitor 1 is a small-molecule research reagent that selectively inhibits Tpl2 (MAP3K8) with biochemical potency (IC50 = 50 nM) and demonstrated cellular activity in monocytes and whole blood. It is supplied as a solid and as a ready-to-use 10 mM solution in DMSO for studies of MAP3K-dependent signaling and inflammatory responses.
- Selective Tpl2 inhibition with IC50 ≈ 50 nM.
- Inhibits LPS-induced TNF-alpha production in human monocytes (IC50 ~0.7-1.1 μM) and whole blood (IC50 8.5 μM).
- Chemical formula C21H14ClFN6; molecular weight 404.83 g/mol.
- High purity (~99.4%).
- Available as solid and as 10 mM solution in DMSO (1 mL).
- Storage: powder at -20 °C; in solvent at -80 °C (6 months) or -20 °C (1 month).
- Intended for use as a research tool to probe inflammatory and cancer-related signaling pathways.
TARGETMOL CHEMICALS INC ALFACALCIDOL 25MG
Also available in 1 mg 2 mg 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Alfacalcidol (Etalpha) (1-hydroxycholecalciferol; Alpha D3; 1.alpha.-Hydroxyvitamin D3) is a non-selective VDR activator medication. purity: 99%
Cayman Chemical ANTIBODY nglIforIb 5mg
A glycogen phosphorylase inhibitor (IC50s = 52, 352, and 150 nM for the liver, muscle, and brain form, respectively); decreases myocardial glycogen phosphorylase activity and infarct size as a percentage of the area at risk in a rabbit model of coronary artery occlusion-induced ischemia-reperfusion injury
Cayman Chemical ANTIBODY APS6-45 10mg
An inhibitor of RETM918T and a derivative of sorafenib; selectively binds to RETM918T over EphA8, p38δ, JNK2, and c-Src (Kds = 28, 410, 940, 1,500, and 1,700 nM, respectively) and a panel of over 60 kinases at 10 µM, but also selectively binds to Cdk14, MAP4K4, and PTK5 (Kds = 55, 130, and 140 nM, respectively); inhibits TT cell colony formation at 30 nM; decreases tumor volume in a TT mouse xenograft model at 10 mg/kg per day; increases survival to adulthood in transgenic Drosophila expressing the lethal RetM955T mutation in a concentration-dependent manner; prevents the development of a rough-eye phenotype induced by RetM955T in transgenic Drosophila at 100 µM;
Cayman Chemical ANTIBODY APS6-45 5mg
An inhibitor of RETM918T and a derivative of sorafenib; selectively binds to RETM918T over EphA8, p38δ, JNK2, and c-Src (Kds = 28, 410, 940, 1,500, and 1,700 nM, respectively) and a panel of over 60 kinases at 10 µM, but also selectively binds to Cdk14, MAP4K4, and PTK5 (Kds = 55, 130, and 140 nM, respectively); inhibits TT cell colony formation at 30 nM; decreases tumor volume in a TT mouse xenograft model at 10 mg/kg per day; increases survival to adulthood in transgenic Drosophila expressing the lethal RetM955T mutation in a concentration-dependent manner; prevents the development of a rough-eye phenotype induced by RetM955T in transgenic Drosophila at 100 µM;
Cayman Chemical ANTIBODY TIoxolon 5g
A carbonic anhydrase I inhibitor (Ki = 91 nM); selective for CAI over CAII, -III, -IV, -VA, -VB, -VI, -VII, -IX, -XII, and -XIV (Kis = 4,930-9,040 nM); active against various Gram-positive or -negative bacteria, including M. tuberculosis; active against dermatophytes, yeasts, and molds
TARGETMOL CHEMICALS INC UK-5099 25MG
Also available in 1 mg 2 mg 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. UK-5099 (PF-1005023) is a specific and potent inhibitor of MPC carrier activity [1]. It potently inhibits pyruvate-dependent oxygen consumption by rat heart mitochondria (IC50 50 nM) [1]. purity: 100%
Cayman Chemical ANTIBODY MHY553 10mg
An agonist of PPARα; activates PPARα in HepG2 cells in a reporter assay at 1 µM but does not activate PPARβ or PPARγ at 10 µM; prevents T0901317-induced triglyceride accumulation in HepG2 cells at 3 µM; scavenges ROS and peroxynitrite in cell-free assays (IC50s = 39.7 and 2.39 µM, respectively); inhibits β-glucuronidase and tyrosinase (IC50s = 8.9 and 0.01 µM for the bovine liver and mushroom enzymes, respectively); reduces age-induced increases in liver weight and triglyceride levels in a rat model of hepatic steatosis at 5 mg/kg
Cayman Chemical ZIyuglycosIde II 5mg
A glycoside with diverse biological activities; cytotoxic to SMMC-7721, PC-9, HCT116, MCF-7, and MDA-MB-231 cancer cells at 30 and 90 UG/ml; increases the number of white blood cells in peripheral blood and the number of HSPCs in a mouse model of cyclophosphamide-induced leukopenia at 6, 12, and 18 mg/kg; reduces small intestinal epithelial cell apoptosis and IL-1β, IL-6, and TNF-α levels, as well as improves diarrhea symptoms in a mouse model of rotavirus-induced diarrhea